Chlorohexidine Di Gluconate %20

CAS Number:

18472-51-0

Chem/ INCI Name: 

Chlorhexidine Digluconate (Chlorhexidine Gluconate, CHG)

Common Form:

Typically supplied as an aqueous solution (e.g., 20% w/v)

Molecular Formula:

C22H30Cl2N10 · 2C6H12O7 or C34H54Cl2N10O14

Molecular Weight:

897.76 g/mol

Uses:

Chlorhexidine Digluconate is a cationic broad-spectrum antimicrobial agent from the bis(biguanide) family. It is the most common water-soluble salt form of chlorhexidine, widely used as a topical antiseptic and disinfectant.

· Healthcare Antisepsis: The gold-standard antiseptic for skin disinfection before surgeries, injections, and catheter insertions to prevent infections.

· Oral Care: Used in prescription mouthwashes and chips to treat gingivitis and periodontal disease.

· General Disinfection & Preservation: Found in surgical scrubs, hand soaps, wound cleansers, and as a preservative in some cosmetics and pharmaceutical products.

What does Chlorhexidine Digluconate  do in a formulation?

· Antimicrobial Agent / Preservative: Its primary function. It acts by binding to and destabilizing microbial cell membranes, causing cell content leakage and death.

· Substantivity: Binds to skin and mucous membranes (like in the mouth), providing prolonged residual antimicrobial activity even after rinsing.

Safety Profile:

· General Toxicity: Considered safe for topical use with low systemic absorption. However, concentrated solutions are for dilution only and can cause severe eye damage.

· Allergic Reactions: Can cause rare but serious allergic reactions, including anaphylaxis. The FDA mandates warnings on labels.

· Specific Warnings:

  · Aquatic Toxicity: Very toxic to aquatic life with long-lasting effects.

  · Use in Infants: Safety not fully established for infants under 2 months; use in preterm infants requires caution.

  · Oral Ingestion: Toxic if swallowed; small amounts can cause gastric distress in children.

Technical profile: