Sodium Ascorbyl Phosphate (Vitamin C)

CAS Number:

66170-10-3

Chemical Name: 

Sodium Ascorbyl Phosphate. Also known as L-Ascorbic acid 2-phosphate trisodium salt

Molecular Formula:

C6H6Na3O9P

Molecular Weight:

322.05 g/mol

Common Form:

White to off-white crystalline powder

EC Number:

425-180-1

Uses:

Sodium Ascorbyl Phosphate is a stable, water-soluble derivative of Vitamin C widely used in cosmetic and personal care formulations for its antioxidant and skin-benefiting properties .

Primary Applications:

· Skin Brightening & Anti-Pigmentation: Effectively inhibits melanin synthesis, helping to reduce hyperpigmentation, age spots, and promote an even skin tone .

· Anti-Aging Formulations: Stimulates collagen production, improving skin elasticity and reducing the appearance of fine lines and wrinkles .

· Antioxidant Protection: Neutralizes free radicals and protects skin from environmental damage such as UV radiation and pollution .

· Acne Treatment: Helps inhibit the growth of acne-causing bacteria (Propionibacterium acnes), making it valuable for anti-acne formulations .

· Daily Skincare: Commonly found in serums, creams, lotions, and moisturizers targeting anti-aging, brightening, and skin repair benefits .

· Cell Culture & Research: Used as a supplement in cell culture media for stem cell and osteoblast differentiation studies .

What does Sodium Ascorbyl Phosphate do in a formulation?

• Stabilized Vitamin C Source: Upon application, skin enzymes convert it into bioactive L-ascorbic acid, providing Vitamin C benefits without stability concerns.
• Antioxidant Agent: Donates electrons to neutralize reactive oxygen species, preventing oxidative stress and skin damage.
• Tyrosinase Inhibitor: Suppresses melanin production by inhibiting tyrosinase activity, leading to skin lightening effects.
• Collagen Synthesis Promoter: Enhances fibroblast activity to stimulate collagen production, improving skin firmness.
• UV Protection Synergist: Works synergistically with sunscreen agents to improve overall UV protection efficacy.
• pH Stabilizer: Maintains optimal efficacy at pH levels between 5.0 and 7.0

Safety Profile:

· Hazard Classification: Generally recognized as safe. Does not meet GHS hazard criteria according to 116 company reports . Not classified as hazardous .

· Skin Tolerance: Gentle and suitable for sensitive skin. Less likely to cause irritation compared to L-ascorbic acid .

· Comedogenicity: Non-comedogenic - does not clog pores, making it suitable for acne-prone skin .

· Potential Side Effects: Some individuals with extremely sensitive skin may experience mild irritation, redness, or itching, though reactions are rare .

· Stability Considerations: Sensitive to moisture, heat, low pH values (<5), and heavy metals . Stable at pH 5-9 and temperatures up to 40°C .

· Storage Requirements: Store in original container, protected from light and moisture, below 25°C . For long-term storage, keep at 0-4°C for short term or -20°C for long term .

· Required PPE: Basic dust protection (safety glasses, dust mask) when handling raw powder. No special requirements for formulated products.

· Shelf Life: 24 months  to 1 year  when stored properly.

Technical profile: