Polysorbate 80

CAS Number:

9005-65-6

Chemical Formula:

C64H124O26

EINECS/ELINCS No:

500-019-9 (Note: This is the standard number for Polysorbate 80, not listed in the provided sources)

COSING REF No:

37415 (Note: This is the standard number for Polysorbate 80, not listed in the provided sources)

Description:

Polysorbate 80 is a non-ionic,hydrophilic surfactant and emulsifier widely used in cosmetics, pharmaceuticals, and food. It is valued for its ability to solubilize oils in water, stabilize formulations, and create stable oil-in-water emulsions.

Uses:

It is a versatile solubilizer and emulsifier used across multiple industries. Its primary role is to blend oil- and water-based ingredients.

· Cosmetics & Personal Care: Found in moisturizers, shampoos, conditioners, lotions, sunscreens, cleansers, and makeup (foundation, mascara). It helps solubilize fragrances and essential oils into water-based products.

· Pharmaceuticals: Used as a stabilizing excipient in injectable formulations, vaccines, and oral medicines to prevent particle formation and improve solubility.

· Food Industry: Approved as an emulsifier (E433) in products like ice cream to improve texture and resistance to melting.

Origin:

Polysorbate 80 is a synthetic (semi-synthetic) ingredient. It is produced by the ethoxylation of sorbitan (derived from sorbitol, a sugar alcohol) followed by esterification with oleic acid. The "80" historically refers to oleic acid. The fatty acid source can be plant-based (e.g., palm oil, olive oil) or synthetic

What does POLYSORBATE 80 do in a formulation?

Its primary functions are:

• Emulsifying (primary)
• Surfactant
• Solubilizing (key function for fragrances/oils)
• Denaturant (in alcohol-based products)

HAZARDS IDENTIFICATION

Classification:

• Physical Hazards: None 
• Health hazards: None
•  Environmental hazards: None 

Label Elements: None 

Signal Word(S): None

 Hazard Statements: None. 

Statement: Keep away from heat and fire. 

Storage: Stored in a cool, dry and ventilated dry place. Keep container tightly closed

COMPOSITION/INFORMATION ON INGREDIENTS

FIRST AID MEASURES

• Eye Contact: Immediately flush eyes with water for at least 15 minutes while holding eyelids open. If irritation persists get medical attention.
• Skin Contact: In case of contact, immediately remove contaminated clothing, and wash with plenty of water. Get medical attention if irritation persists. Clean contaminated clothing and shoes before reuse
• Inhalation: Inhalation is not an expected route of exposure. If respiratory irritation or distress occurs remove victim to fresh air. Seek medical attention if respiratory irritation or distress continues.
• Ingestion: Oral toxicity is low. If ingesting, get medical attention
• Comments: Treat according to person’s condition and specifics of exposure. Skin contact may aggravate existing skin disease.
• Note to Physicians: Treat symptomatically.

FIRE-FIGHTING MEASURES

• Extinguishing Media: Use water, carbon dioxide, foam, dry powder.
• Fire & Explosion Hazards: May ignite by sparks, heat flames. Carbon dioxide and carbon dioxide may be released by fire.
• Special Fire-fighting Protective Equipments: Firefighters should wear NIOSH/MSHA approved self-contained breathing apparatus and full protective clothing.

ACCIDENTAL RELEASE MEASURES

• Personal Precautions: Avoid eyes/face contact. Avoid skin contact. Do not take internally.
• Environmental Precautions: Do not allow to penetrate into soil, water bodies or drains.
• Methods for Cleaning Up: Contain spillage, and then collect with non-combustible absorbent materials, (e.g. sand, dry lime, soda ash) and place in container for disposal according to local/ national regulations. It can also be diluted with a large amount of water before release into the waste water system. For large spill, use dike to contain and then collect, transfer, recycle or discard after treatment.

HANDLING AND STORAGE

• Handling Precautions: Avoid contact with skin and eyes. Wash thoroughly after handling. As all chemicals, good industrial hygiene practices should be followed when handling this material.
• Storage Conditions: Keep containers tightly closed in a dry, cool and well -ventilated place. Keep away from kindling material, heat source and direct sun light，Do not store close to strong oxidizing agents which could aggravate any fire situation.

EXPOSURE CONTROLS/PERSONAL PROTECTION

• Engineering Measures: Provide adequate ventilation
• Eye Protection: Safety goggles recommended.
• Skin Protection: Protective overalls and safety shoes/boots recommended.
• Hand Protection: Impervious gloves recommended.
•  Respiratory Protection: Not required. 
•  Others: Eyewash and safety shower easily accessible to the work area

PHYSICAL AND CHEMICAL PROPERTIES

•  Appearance: Light yellow to yellow oily liquid. 
•  Odor: Characteristic 
•  Melting Point: Unknow 
•  pH(25℃)(1%soln.): Unknow 
•  Boiling Point: Unknow
•   Flash Point: ＞120°C （Closed cup） 
•  Vapor pressure: Unknow

STABILITY AND REACTIVITY

• Stability: Stable under normal conditions. 
• Incompatible Materials: Avoid strong oxidizing agents and acids. 
•  Conditions to Avoid: Heat, open flame, spark.
•  Hazardous Polymerization: Hazardous polymerization will not occur.

TOXICOLOGICAL INFORMATION

• Carcinogenicity: Not considered to be a carcinogen according the animal tests. 
•  Teratogenicity: Not available 
•  Mutagenicity: Testing has shown this product to be non-mutagenic when make the rats expose in 100mg/ml products for 24h.

ECOLOGICAL INFORMATION

• Ecological Toxicity: None Established. 
•  Persistence and Degradability: It is biodegradable in the environment.
• Mobility: The product will dissolve in water.

DISPOSAL CONSIDERATIONS

• Product Disposal: Dispose of in accordance with local regulations.
•  Packaging Disposal: Any containers or equipment used should be decontaminated immediately after use

TRANSPORT INFORMATION

•  Road and Rail Transport: Not subject to ADR/RID code. 
•  Sea Transport (IMDG): Not subject to IMDG code. 
• Air Transport (ICAO/IATA): Not subject to ICAO/IATA regulations.

REGULATORY INFORMATION

Applicable Laws: Provisions of the Regulations for the Safe Handling of Chemicals in the Workplace, particularly those relating to the safe use, production, storage and transportation of dangerous chemicals. 

Chemical Inventories:

•  AICS: All ingredients listed or exempt. 
• DSL: All chemical substances in this material are included on or exempted from the DSL. 
• IECSC: All ingredients listed or exempt. 
• MITI: All components are listed on ENCS or its exempt rule. 
• KECL: All ingredients listed, exempt or notified.
•  EINECS: All ingredients listed or exempt. 
• PICCS: All ingredients listed or exempt. 
• TSCA: All chemical substances in this material are included on or exempted from listing on the TSCA Inventory of Chemical Substances.

Technical Specifications

Packaging

200kg/ plastic drum or 1000kg/IBC net weight.

Storage And Preservation

Preserved dry at room temperature, avoid sunlight.

Shelf Life

2 years