Menthol Crystal

CAS Number:

89-78-1 (for racemic DL-menthol) or 2216-51-5 (for the natural L-(-)-isomer)

Chemical  / INCI Name:

Menthol. The pure isomer is often specified as L-Menthol or (-)-Menthol.

Molecular Formula:

C10H10O

Molecular Weight:

156.27 g/mol

Common Form:

Colorless or white crystalline solid, forming characteristic needle-like or prismatic crystals. Has a strong, penetrating peppermint odor.

Uses:

Menthol activates cold-sensitive TRPM8 receptors in the skin and mucous membranes, producing a profound cooling sensation without an actual temperature change. This defines its vast range of applications.

Primary Applications:

· Pharmaceuticals & Topical Analgesics: A key active ingredient in balms, creams, and patches for relieving muscle aches, minor arthritis pain, and itching (e.g., Icy Hot, Tiger Balm).

· Personal Care & Cosmetics: Used in toothpaste, mouthwash, lip balms, aftershaves, and shampoos for its cooling feel and freshening effect.

· Flavor & Fragrance Industry: Provides the characteristic mint flavor in confectionery (candies, gum), beverages, liqueurs, and culinary products. Used in perfumery for fresh, clean notes.

· Tobacco & Vaping Products: Added to cigarettes, smokeless tobacco, and e-liquids to provide a cooling throat sensation.

· Aromatherapy & Inhalants: Used in chest rubs and inhalers to relieve nasal congestion and cough symptoms.

What does Menthol Crystals do in a formulation?

• Counterirritant & Analgesic: Its primary pharmacological action. The cooling sensation can override and mitigate the perception of pain or itch.
• Flavor & Fragrance Agent: Provides a pure, intense minty flavor and aroma.
• Cooling Sensate: Imparts a immediate and long-lasting cooling effect on skin and mucous membranes, enhancing product sensory appeal.
• Mild Local Anesthetic: In higher concentrations, can have a slight numbing effect.
• Decongestant: The cooling vapor sensation can create a subjective feeling of easier breathing.

Safety Profile:

· Hazard Classification: Generally considered safe for use but with specific warnings. Can be harmful if swallowed in large amounts. Causes serious eye irritation.

· Skin Contact: Generally safe at low concentrations (1-2%). Can cause skin irritation, allergic dermatitis, or a burning sensation in sensitive individuals or at high concentrations (>16%).

· Eye Contact: Dust or crystals cause severe eye irritation. Flush immediately with water.

· Ingestion: Toxic in large quantities. Oral LD?? (rat) is ~3,300 mg/kg. Ingestion of pure menthol (e.g., by children) can cause throat burning, nausea, and systemic effects.

· Required PPE: Safety glasses and gloves are recommended when handling pure crystals to prevent eye contact and skin irritation.

· Special Sensation Note: The "cooling" is a neurological trick, not a temperature change. It does not treat inflammation or reduce actual tissue temperature.

Technical profile: