Low Molecular Weight Hyaluronic Acid (LMW HA)

CAS Number:

9004-61-9 (for Hyaluronic Acid). 9067-32-7 (for Hydrolyzed HA)

Product Name:

Low Molecular Weight Hyaluronic Acid (LMW HA). Often referred to as Hydrolyzed Hyaluronic Acid or Oligo Hyaluronic Acid depending on the specific molecular weight range.

Chemical Family / INCI Name:

Glycosaminoglycan. INCI: Hydrolyzed Sodium Hyaluronate (for oligosaccharides) or Sodium Hyaluronate (for certain LMW ranges)

EC Number:

232-678-0

Common Form:

White or almost white powder or granules

Uses:

Unlike high molecular weight HA which forms a protective film on the skin's surface, low molecular weight HA is designed to penetrate deeper layers for multi-dimensional moisturizing and bioactive effects.

Primary Function and Applications:

· Primary Function: Deep moisturizer, skin conditioner, anti-aging agent, and cell signaling modulator .

· Key Benefit: Rapid penetration into the epidermis and dermis to provide deep hydration, stimulate collagen production, scavenge free radicals, and support skin barrier function .

· Typical Applications:

  · Advanced Skincare: Serums, face masks, eye creams, and anti-aging formulations targeting deep hydration and wrinkle reduction .

  · Hair Care: Scalp treatments and conditioners for improved moisture retention.

  · Aesthetic Medicine: Component in some dermal fillers and topical pre-treatment formulations .

  · Biomedical Applications: Wound healing formulations and drug delivery systems due to its tissue regeneration properties .

What does Low Molecular Weight Hyaluronic Acid  do in a formulation?

• Deep Penetration & Hydration: Due to its reduced molecular size, it penetrates through the stratum corneum into deeper epidermal layers (and potentially the dermis), delivering moisture where high molecular weight HA cannot reach . The penetration rate can be up to 3 times faster than standard low molecular weight HA .
• Collagen Stimulation: Studies show it increases the expression of COL1A1 (collagen synthesis gene) and ultimately increases dermal collagen density, reducing wrinkle depth .
• Barrier Support: Drives production of the skin barrier protein filaggrin (FLG) and natural moisturizing factors (NMF), enhancing overall skin barrier integrity .
• Free Radical Scavenging: Helps neutralize free radicals and reduces inflammation factor activity, protecting skin from environmental stressors .
• Cell Signaling: Supports extracellular matrix stability and cell signaling crucial for tissue repair and regeneration .

Safety Profile:

· Safety Note: Generally recognized as safe for topical use. Well-tolerated with rare adverse effects; suitable for all skin types . Produced via non-GMO fermentation (typically Streptococcus zooepidemicus), ensuring animal-free, non-animal source material .

· Storage Conditions: Store in a cool, dry place in tightly sealed, lightproof containers. Long-term storage recommended at 2-8°C for optimal stability .

· Shelf Life: 2 years at 25°C; can extend to 5 years at 4°C .

Technical profile: