High Molecular Weight Hyaluronic Acid

CAS Number:

9004-61-9 (Hyaluronic Acid); 9067-32-7 (Sodium Hyaluronate)

Product Name:

High Molecular Weight Hyaluronic Acid

Chemical Family / INCI Name:

Glycosaminoglycan. INCI: Sodium Hyaluronate

EC Number:

232-678-0

Common Form:

White or off-white powder, fibrous or granular

Uses:

High molecular weight HA provides exceptional surface hydration and film-forming properties, remaining on the skin surface to deliver immediate, visible moisturizing effects.

Primary Function and Applications:

· Primary Function: Surface moisturizer, film-forming agent, viscosity enhancer, and viscoelastic supplement

· Key Benefit: Forms a protective, hydrating film on the skin's surface that instantly smooths, plumps, and reduces transepidermal water loss (TEWL)

· Typical Applications:

  · Cosmetic & Skincare: Day creams, night creams, serums, masks, and lotions for immediate surface hydration and anti-wrinkle effects

  · Medical Devices: Intra-articular injections for osteoarthritis pain relief

  · Eye Care: Eye drop formulations for dry eye relief (ophthalmic grade)

  · Wound Healing: Hydrogel dressings and topical formulations

What does High Molecular Weight Hyaluronic Acid do in a formulation?

• Surface Hydration: Due to its large molecular size (typically >1,000 kDa), it cannot penetrate the stratum corneum. Instead, it forms a viscoelastic film on the skin surface that holds up to 1000 times its weight in water, providing immediate and intense surface hydration
• Film-Forming Barrier: Creates a flexible, breathable film that protects against environmental stressors and reduces water loss
• Plasticizer & Viscosity Modifier: Softens and adds flexibility to films (e.g., in capsule shells) and adjusts the flow properties of liquids and creams.
• Viscosity Enhancement: Significantly increases the viscosity of aqueous phases, improving formulation stability and sensory properties
• Lubrication: Provides exceptional lubricity, making it ideal for ophthalmic and intra-articular applications

Safety Profile:

· Safety Note: Generally recognized as safe for topical and approved medical use. Non-toxic, non-irritating, and biocompatible

· Handling Recommendations: For powder handling, wear dust mask, chemical safety goggles, and gloves to avoid mechanical irritation

· Storage Conditions: Store in a cool, dry place (-20°C to 8°C recommended for long-term) in tightly sealed, light-protected containers. Hygroscopic - protect from moisture

· Shelf Life: Typically 2 years when stored properly under recommended conditions

Technical profile:

Formulation Notes:

1. Solubility: Dissolves slowly in water with gentle agitation. Avoid high shear to prevent molecular weight degradation.

2. Stability: Solutions are susceptible to microbial degradation; use preservatives appropriately.

3. pH Stability: Optimal stability at pH 6.0-7.5.