Alpha-Arbutin

CAS Number:

84380-01-8

Chemical Name: 

Alpha-Arbutin. Also known as 4-Hydroxyphenyl-α-D-glucopyranoside

Molecular Formula:

C12H16O7

Molecular Weight:

272.25 g/mol

Common Form:

White crystalline powder

EINECS/ELINCS Number:

617-561-8

Uses:

Alpha-Arbutin is a functional skin-lightening active ingredient widely used in cosmetics and skincare. It is considered a safer and gentler alternative to hydroquinone.

Primary Applications:

· Skincare (Skin Lightening/Brightening): The primary function. It is used to reduce the appearance of hyperpigmentation, age spots, melasma, and post-inflammatory hyperpigmentation (such as acne scars), promoting an even skin tone.

· Cosmetic Products: Incorporated into formulations to impart a brightening and illuminating effect on the skin, contributing to a more youthful and radiant appearance.

· Antioxidant Protection: Possesses antioxidant properties that help protect the skin from oxidative stress, free radicals, and environmental pollutants .

What does Alpha-Arbutin do in a formulation?

• Whitening/Lightening Agent: The core function; it works by inhibiting the enzyme tyrosinase, which is responsible for melanin production in the skin.
• Antioxidant: Inhibits oxygen-mediated reactions, preventing the oxidation and degradation of other ingredients in the formulation and protecting the skin.
• Skin Conditioning Agent: Improves the appearance of dry and/or damaged skin by reducing flaking and restoring suppleness.
• Color Stabilizer: Helps maintain a uniform and fresh skin tone.

Safety Profile:

· Hazard Classification: Generally considered safe for use in cosmetics. It has a low potential for causing skin irritation when used at recommended concentrations .

· Potential Side Effects: Although rare, it may cause dermatitis or skin sensitivity in some individuals. Discontinue use immediately and consult a physician if any adverse effects occur .

· Special Warning: There is a minimal possibility of the release of hydroquinone (which is banned in cosmetics) from arbutin during manufacturing, storage, or use, especially upon exposure to UV radiation or microorganisms. Therefore, high purity of the raw material and the stability of the final formulation are critically important .

· Pregnancy and Breastfeeding: It is advisable to avoid use during pregnancy and lactation as a precaution due to the lack of sufficient studies confirming its safety .

· Required PPE (Personal Protective Equipment): Safety glasses and a dust mask when handling the raw powder in laboratories or manufacturing facilities. No specific requirements for the end consumer.

· Storage and Handling Note: Store in a cool, dry place away from direct light, as exposure to light or heat may reduce its efficacy or cause instability . The optimal pH stability range is 5-7 .

Technical profile: