Allantoin

CAS Number:

97-59-6

Chemical Name: 

Allantoin. Also known as 5-Ureidohydantoin, Glyoxyldiureide

Molecular Formula:

C4H6N4O3

Molecular Weight:

158.12 g/mol

EC Number:

 202-592-8

Common Form:

White to off-white crystalline powder, odorless

Uses:

Allantoin is a natural compound found in the human body and many plants (such as comfrey, sugar beet, wheat sprouts) . It is widely used in cosmetics, personal care, and skincare products for its soothing, moisturizing, and wound-healing properties .

Primary Applications:

· Skincare & Moisturizing Products: A key ingredient in moisturizing creams, lotions, serums, and eye and face care products. It hydrates, soothes, and improves skin texture .

· Acne Treatment Products: Used in skincare for acne-prone skin due to its soothing and gentle exfoliating properties .

· Wound & Burn Healing Products: Incorporated into ointments and creams formulated for treating minor wounds, burns, scratches, and skin cracks .

· Oral Care Products: Found in toothpastes, mouthwashes, and other oral hygiene products .

· Hair & Scalp Care Products: Used in shampoos and conditioners to soothe dry, flaky scalps, reduce frizz, and moisturize hair .

· Cosmetics: Included in lipsticks, mascaras, foundations, and other makeup products .

· Baby Products: Found in tear-free baby shampoos, lotions, and diaper creams due to its gentle and safe nature .

What does Allantoin  do in a formulation?

• Humectant: Attracts water from the deeper layers of the skin and the surrounding air, increasing moisture content in the upper layers and deeply hydrating the skin .
• Soothing Agent: Calms irritated and sensitive skin, reducing redness and swelling due to its anti-inflammatory properties.
• Keratolytic Agent (Gentle Exfoliant): Helps soften proteins in dead skin cells, facilitating gentle exfoliation and removal of dead surface layers, revealing smoother, brighter skin .
• Wound Healer: Stimulates cell proliferation and increases collagen deposition, accelerating wound healing and restoring normal skin .
• Anti-irritant: Forms a protective layer on the skin and complexes with irritating substances, reducing their harmful effects .
• Skin Protectant: Forms a protective barrier that locks in moisture and protects the skin from harmful external factors and irritants .

Safety Profile:

· Hazard Classification: Generally Recognized as Safe (GRAS) . Not classified as hazardous in normal uses. Considered non-toxic and non-irritating to skin .

· Skin/Eye Contact: May cause mild mechanical irritation in powder form. In finished formulations, considered non-irritating and safe for use around the eyes and in oral care products .

· Inhalation: Powder dust may irritate the respiratory tract. Avoid dust inhalation during manufacturing.

· Ingestion: Safe for use in oral care products such as toothpaste and mouthwash .

· Pregnancy and Breastfeeding: Studies showed no increased congenital abnormalities in children of 51 women who used allantoin during the first trimester . However, consulting a physician before use is advised .

· Environmental Impact: Natural and biodegradable, environmentally safe.

· Required PPE: Safety glasses and dust mask when handling raw powder in manufacturing or laboratory settings. No special requirements for end consumers.

· Storage and Handling Note: Store in a cool, dry place (between 20-25°C) away from moisture and direct sunlight . Shelf life up to 36 months under proper conditions .

Technical profile: